Journal of Spectral Imaging,   Volume 3   Article ID a2   (2012)

Peer reviewed Paper

Study of component distribution in pharmaceutical binary powder mixtures by near infrared chemical imaging

  • Manel Bautista
  • Jordi Cruz
  • Marcelo Blanco
Escola Universitària Salesiana de Sarrià, Passeig Sant Joan Bosco, 74, 08017 Barcelona, Spain

 https://orcid.org/0000-0001-8191-8689
 Search for papers by this author
Unidad de Química Analítica, Departamento de Química, Facultad de Ciencias, Universidad Autónoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

 Search for papers by this author
 Corresponding Author
Unidad de Química Analítica, Departamento de Química, Facultad de Ciencias, Universidad Autónoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
[email protected]
 Search for papers by this author

Near infrared chemical imaging (NIR-CI) has recently emerged as an effective technique for extracting spatial information from pharmaceutical products in an expeditious, non-destructive and non-invasive manner. These features have turned it into a useful tool for controlling various steps in drug production processes. Imaging techniques provide a vast amount of both spatial and spectral information that can be acquired in a very short time. Such a huge amount of data requires the use of efficient and fast methods to extract the relevant information. Chemometric methods have proved especially useful for this purpose. In this study, we assessed the usefulness of the correlation coefficient (CC) between the spectra of samples, the pure spectra of the active pharmaceutical ingredient (API) and we assessed the excipients to check for correct ingredient distribution in pharmaceutical binary preparations blended in the laboratory. Visual information about pharmaceutical component distribution can be obtained by using the CC. The performance of this model construction methodology for binary samples was compared with other various common multivariate methods including partial least squares, multivariate curve resolution and classical least squares. Based on the results, correlation coefficients are a powerful tool for the rapid assessment of correct component distribution and for quantitative analysis of pharmaceutical binary formulations. For samples of three or more components it has been shown that if the objective is only to determine uniformity of blending, then the CC image map is very good for this, and easy and fast to compute.

Keywords: correlation coefficient, NIR chemical imaging, homogeneity, concentration maps, pharmaceutical samples

Metrics

Downloads:

892

Full-Text HTML Views:

184

Abstract Views:

1,303