Journal of Spectral Imaging,   Volume 9   Article ID a13   (2020)

Peer reviewed Review

Emerging applications in mass spectrometry imaging; enablers and roadblocks

  • Cristina Russo
  • Cameron Heaton
  • Lucy Flint
  • Oana Voloaca
  • Sarah Haywood-Small
  • Malcolm Ronald Clench
  • Simona Francese
  • Laura Margaret Cole
Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK

 https://orcid.org/0000-0002-9776-8897
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0002-4479-3861
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0001-6187-3081
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0003-0131-6907
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0002-8374-9783
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0002-0798-831X
 Search for papers by this author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK

 https://orcid.org/0000-0002-1381-1262
 Search for papers by this author
 Corresponding Author
Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK
[email protected]
 https://orcid.org/0000-0002-2538-6291
 Search for papers by this author

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

Keywords: mass spectrometry imaging (MALDI), secondary ionisation mass spectrometry (SIMS), desorption electrospray ionisation (DESI), laser ablation inductively coupled plasma (LA-ICP), liquid extraction surface analysis (LESA), imaging mass cytometry (IMC), biomolecular imaging, technical advancements, imaging software

Metrics

Downloads:

331

Full-Text HTML Views:

1

Abstract Views:

571