Quality Assurance and Quality Control (QA/QC) is of critical interest in the mining industry. Over the years, Anglo American Platinum has adopted a sound strategy of Best Practice Principles (BPP) for mass measurement, sampling, sample preparation, analysis, and metal accounting. Often, much effort is focused on implementation and maintenance of quality control systems to provide quality assurance. Within the Anglo American Platinum business units, QA/QC data are deemed of significant value on a day-to-day basis and on a higher level also provides a means to prove or disprove evaluation and metal accounting disputes between various sites and/or opposing members of the Joint Evaluation Committee (JEC). Unfortunately, QA/QC data and associated QA/QC systems alone do not always provide the technical or tangible reasons to supplement explanations around anomalies in performance. It is sometimes necessary to go beyond monitoring and focus on interpreting the QA/QC data to comprehend the underlying issues. This paper aims to showcase a multitude of actual case studies pertaining to troubleshooting of challenges encountered throughout the Platinum processing pipeline (i.e., Concentrator to Smelter to Refinery). These challenges range from areas of mass measurement to sampling, to sample preparation and analytical as well as plant performance. Observations and learnings from these instances indicated that even though stringent QA/QC was adhered to, it was evident that complying to first principles of mass measurement and sampling theory, minimum sample mass and an ongoing understanding of individual material characteristics was crucial. It was also highlighted that the re-assessment of designs, methods and protocols are necessary per material stream and that a standardization approach across all Anglo American Platinum business units is perhaps sensible at one time but may not always be appropriate and/or relevant.